Diseases

Tadalafil

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The active substance Tadalafil belongs to the most important means for the treatment of the erectile dysfunction (impotence). He belongs to the drug class of PDE-5 inhibitors. Compared to the other members of this class (sildenafil, vardenafil, avanafil) Tadalafil has a much longer duration of action in the body. Here you can read everything important about the effects and use of Tadalafil, side effects and contraindications.

ArtikelübersichtTadalafil
  • operation
  • application areas
  • Proper application
  • side effects
  • Important instructions
  • tax provisions
  • history

This is how Tadalafil works

Erectile dysfunction

The male erection occurs after sexual arousal, either through psychic stimuli or mechanical stimulation. Nerve signals that release messenger substances in the blood vessels of the penis lead to a blood filling of the erectile tissue of the penis. Among other things, the messenger "cGMP" plays a decisive role. It dilates the afferent blood vessels, allowing more blood to enter the cavernous bodies - the limb becomes stiff. Gradually, however, this messenger substance is broken down, not least to let the penis relax after intercourse again.

In erectile dysfunction, the inability to get or maintain an erection, PDE-5 inhibitors such as Tadalafil are used: They inhibit a specific enzyme (phosphodiesterase 5, PDE-5 short), which degrades the messenger cGMP. As a result, the blood level of cGMP remains elevated, which improves erectile function.

Benign enlargement of the prostate (benign prostatic hyperplasia)

Similar to the penile tissue, the vessels of the prostate and the bladder also behave. Again, by inhibiting cGMP degradation, tadalafil can relax the muscles in the vessel walls - the blood vessels dilate, improving blood flow. This has a positive impact on the progression of benign prostate enlargement.

High blood pressure of the pulmonary artery (pulmonary arterial hypertension)

In the case of pulmonary hypertension, there is too high a blood pressure in the pulmonary circulation (more precisely: in the pulmonary artery). Tadalafil can also help to relax the blood vessels and lower blood pressure. This protects the vascular walls and organs involved in the long term.

Uptake and degradation of Tadalafil

Tadalafil is well absorbed into the body after oral intake and reaches its maximum concentration in the blood after two hours. In the liver, the active ingredient is degraded to inactive metabolites. After about 17.5 hours, half of the drug is eliminated - two-thirds over the stool, one-third over the urine.

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When will Tadalafil be used?

The active substance tadalafil is used to treat the following diseases:

  • erectile dysfunction in adult men
  • Pulmonary hypertension (pulmonary arterial hypertension)

The treatment is usually longer term. Only in the case of erectile dysfunction is it possible to take a situation-adapted, isolated intake.

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This is how Tadalafil is used

The active ingredient is distributed in Germany only in the form of tablets. To treat the erectile dysfunction it should be taken at least half an hour before sexual activity - usually ten milligrams of tadalafil are taken. It is also possible to take five milligrams daily, regardless of any planned sexual activity. Thus, a constant drug level can be achieved in the blood, making you more free in the planning.

The intake at benign prostate enlargement and Pulmonary hypertension takes place once a day. The usual dose of tadalafil is five milligrams or forty milligrams. The intake should always take place approximately at the same time of day.

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What are the side effects of Tadalafil?

Tadalafil side effects such as headache, redness, stuffy nose, indigestion, acid regurgitation, back pain, muscle aches and joint pain occur in every tenth to one hundredth patient.

In addition, hypersensitivity reactions, dizziness, blurred vision, eye pain, tinnitus, accelerated heartbeat, low or high blood pressure, dyspnea, epistaxis, abdominal pain, skin rash, increased sweating, urinary blood, and chest pain occur in every one hundredth to one thousandth person.

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