Diseases

Autoantibodies

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Autoantibodies are antibodies that are directed against the body's own, healthy tissue. As a result, an autoimmune disease develops. Read more about the different types of auto-antibodies and their diseases!

Article overview autoantibodies

  • What are auto-antibodies?
  • When will auto-antibodies be determined?
  • What are auto-antibodies determined of?
  • When is the auto-antibody value too high?

What are auto-antibodies?

Auto-antibodies are antibodies (antibodies) that produce the immune system from a morbid dysregulation against the body's own cells or tissues. Doctors then speak of one Autoimmune disease, Most often, they are noticeable in early adulthood: Under the influence of unknown triggers in the environment and certain hereditary factors, the immune system produces auto-antibodies that attack the body's own tissue.

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When will auto-antibodies be determined?

The doctor has auto-antibodies determined if he suspects autoimmune disease in the patient. However, he never sets the diagnosis solely on the basis of the laboratory value.

Examples of autoimmune diseases and their corresponding antibodies:

Autoimmune disease

Autoantibodies

Type 1 Diabetes

ICA (islet cell antibodies)

GADA (glutamate decarboxylase antibody)

IA2-AK (tyrosine phosphatase antibody)

Insulin antibody

Graves' disease

TPO-AK (thyroid oxidase antibody)

MAK (antibodies against microsomal thyroid antigen)

Hashimoto's thyroiditis

TgAK (thyroglobulin antibodies)

TPO-AK (thyroid oxidase antibody)

Myasthenia gravis

AchR-AK (acetylcholine receptor antibody)

Skeletal muscle antibodies)

Rheumatoid arthritis

RF (rheumatoid factor)

Rheumatic diseases (such as lupus erythematosus, rheumatoid arthritis, panarteritis nodosa)

ANA (antinuclear antibodies)

Chronically active hepatitis

SMA (smooth muscle antibodies)

ANA (Antunuclear antibodies)

Autoimmune hepatitis

LKM (Liver-Kidney-Microsomal Antibodies)

Type 1 Diabetes

IA2-AK (tyrosine phosphatase antibody)

Type 1 Diabetes

IA2-AK (tyrosine phosphatase antibody)

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What are auto-antibodies determined of?

The doctor needs a normal blood sample to determine auto-antibodies.

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When is the auto-antibody value too high?

Auto-antibodies are very important in the diagnosis of autoimmune diseases. Sometimes they can be found in the blood even before the onset of the disease. However, the detection of autoantibodies does not prove that the patient has the disease. The physician must also take into account the patient's complaints and any other examination results.

Low levels of autoantibodies may also be found in healthy individuals, such as mildly elevated ANA or rheumatoid factors in smokers, women taking the pill or in the elderly.

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